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The purpose of this study was to test the stability of TPN basic solutions containing amino acids and dextrose. Test solutions containing 4.25% amino acids in 25% dextrose (central TPN basic solution) or 4.25% amino acids in 10% dextrose (peripheral TPN basic solution) were prepared. Two different amino acids solutions (Fravasol^{(R)};vs;Freamine^{(R)}) were tested. The samples were taken from each admixture and stored in the evacuated, sterile containers at 2{sim}8^{circ}C and ambient room temperature. Each sample was analyzed at 0, 3, 7, 14 and 30 days of storage. Each amino acid was analyzed by amino acid analyzer. Dextrose content was measured by polarimeter. The pH and chromagen formation were also monitored. The decomposition was measured by the changes in concentration of amino acids and dextroser TPN basic solution-Freamine^{(R)} admixture stored at 2sim8^{circ}C were stable for 30 days. Central and peripheral TPN basic solutions stored at room temperature were stable for 7 days and 14 days, respectively. There were no changes in color for 30 days by naked eye. Amino acid concentrations in TPN basic solution-Fravasol^{(R)} admixture stored at 2sim8^{circ}C or room temperature were stable for 30 days. But, significant color change was detected according to passing time. In conclusion, Peripheral TPN basic solution-Fravasol^{(R)} admixture stored at room temperature and in refrigerator were stable for 3 days and 7 days, respectively. However, central TPN basic solution-Fravasol admixtures were unstable. Therefore, it is recommended that it should be admixed right before use.
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